A medication that is given through the skin would be administered via which route?

The correct choice is subcutaneous. Medications administered through the skin typically involve injection into the subcutaneous tissue, which lies just beneath the outer layer of skin. This route allows for the gradual absorption of medication into the bloodstream.

In addition, the subcutaneous route is commonly used for various types of drugs, including insulin and some vaccines, where a slow, sustained release into the bloodstream is desired. The method is advantageous for self-administration and can be performed with little discomfort.

Other routes such as intramuscular and intravenous involve penetration deeper into muscle tissue or direct injection into the bloodstream, respectively, which do not align with the skin administration concept. Buccal administration refers to placing medication between the gum and cheek, which is also not applicable to skin administration.